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The Role of the Liver in Multi Organ Failure
Dr. Steinhardt, why is it that liver patients so often suffer from multi organ failure? So you want to look and step back, look at what the liver does and how its dysfunction affects other organs. Necrosis will cause severe and rapid loss of metabolic function resulting in decreased gluconeogenesis, decreased lactate clearance, decreased synthetic ability. Albevin decreased ammonia clearance. This causes metabolic alkalosis, hypokalemia, hyponatremia, hypofosphatemia, and magnesemia. And you get high output cardiac failure with this azotemia and cephalopathy.