Germline Predisposition Testing in Potential Stem Cell Donors

Germline predisposition testing on patients heading to transplant and on their potential donors is feasible but it will require a large shift in how we all conduct the evaluation of patients and their donors. I am now very cautious about the unrelated donor pool knowing how common DDX41 and check to deleterious variants are. The transplantation right now probably is not conducted with enough disclosure to individuals when they donate, he says.