Pattern Recognition

Many leading edge scientists today say that we can't know ultimate reality, simply because we're limited to what's being detected by our various senses. And it reminds me of that famous scene from the Matrix movie: Right now, we're inside a computer program. Is it really so hard to believe? Your clothes are different. The plugs in your arms and head are gone. Your hair has changed. This isn't real. What is real? How do you define real?