Would You Consider a Small Pressor or a Big Publisher for Your Fiction?

I think for my fiction, at this point, i would consider a big publisher. With the distribution, microcosm just, they have me beat completely. There's no way that i could get that level of distribution or at least for physical books. I really feel this is what we need to be doing as as indies. We want to be independent, but that doesn't mean working alone, does it?