Clozapine: A Revolutionary Treatment Overview

This chapter explores the development and FDA approval process of clozapine for treatment-resistant psychiatric patients, detailing the challenges and successes of Study 30. It further examines the historical safety measures instituted to mitigate risks, including mandatory blood testing to prevent severe side effects. Additionally, the discussion addresses the ongoing underutilization of clozapine, the pharmacological intricacies of its action, and the significant adverse effects like hypersalivation that require careful management.