Muscle Protein Synthesis and Anabolic Resistance

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Detailed analysis of muscle protein synthesis and anabolic resistance, covering topics like turnover of muscle proteins, amino acids as signaling molecules, factors affecting muscle protein synthesis, differences in milk proteins, and impact of aging and inactivity on muscle protein synthesis. The chapter explores the concept of anabolic resistance, discussing factors like aging-related decline in amino acid uptake and mTOR signaling, along with comparisons between protein sources for muscle synthesis.

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In this quarterly podcast summary (QPS) episode, Peter introduces a new format aimed at summarizing his biggest takeaways from the last three months of guest interviews on the podcast. Peter shares key insights from each episode, covering diverse topics such as protein and muscle building with Luc van Loon, toe strength with Courtney Conley, VO2 max with Olav Aleksander Bu, liquid biopsies for cancer with Alex Aravanis, gut health and probiotics with Colleen Cutcliffe, and road safety with Mark Rosekind. Additionally, Peter shares any personal behavioral adjustments or modifications to his patient care practices that have arisen from these engaging discussions.

If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the episode #304 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

We discuss:

How Peter keeps track of his takeaways from each podcast episode [5:15];
Luc van Loon episode: fat utilization, muscle protein synthesis, dietary protein, aging and inactivity, and more [8:45];
Behavioral changes that have come about from the conversation with Luc van Loon [23:45];
Courtney Conley episode: importance of toe strength and the impact of dedicated foot training [26:45];
Olav Aleksander Bu episode: the importance of VO2 max for lifespan, and the practicalities of measuring and improving VO2 max [36:45];
Behavioral changes that have come about from the conversation with Olav [56:00];
Alex Aravanis episode: liquid biopsies for cancer detection [1:01:30];
Colleen Cutcliffe episode: the importance of gut bacteria balance, and the potential therapeutic uses of probiotics, particularly Akkermansia [1:16:45];
Mark Rosekind: the significant issue of road fatalities and injuries, their causes, and practical safety measures to reduce risks [1:27:00]; and
More.

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