The hosts talk about the excitement of exploring life in the universe, mentioning tools like the James Webb telescope. The chapter features a conversation with Lisa Kaltenegger, an astrophysicist, about her research on modeling habitable worlds and the search for signs of life on exoplanets. They discuss potential indicators of life like the combination of oxygen and methane in a planet's atmosphere and delve into the complexities of defining and identifying life beyond Earth.

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