Is there any other way to prevent a baby from inheriting mutated mitochondria? One could of course undergo prenatal diagnosis, so establish a pregnancy. I'm not aware at the moment of any effective treatment of children that are born with the disease. There's an alternative method where the nucleus of the mother's egg is swapped into the donor egg before it's fertilized. But you would have to be able to edit sufficient numbers of mitochondria in that cell. And that brings a whole set of other ethical questions along with it.