Evaluating the Results of Platform Clinical Trials: A Guide for Clinicians
JAMA Clinical Reviews
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Can a Platform Trial Maintain Its Rigidity in Changing Clinical Standards?
The standard of care has changed in a variety of conditions over the last few years. This creates a problem for platform trials, because you're making changes during the conduct of a trial. And it's very rare that a condition would change as rapidly as has occurred during covid. It gives you an option of either ing your trial ind starting again, and then you have the risk that there's going to be another big shift in standard of care.
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