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Hunger, weight loss and obesity | Stephan Guyenet, PhD

The Proof with Simon Hill

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The Effects of the JYP1 Agonist on the Brain

The JYP1 agonist is acting on the brain to essentially help normalize a dysregulated appetite. I think you could maybe argue that it's normalizing, but I'm kind of reluctant to use the word normalized because these drugs are ramping up that signal way beyond physiological levels. These drugs are going into the brain and activating GLP1 receptors way beyond what a normal person would experience. So it certainly can feel like a normalization. It's not really restoring you to normal physiology.

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