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Gut microbiota and outcomes in DLBCL, NFIA-ETO2 fusion cooperates with TP53 in leukemogenesis, and the impact of nirmatrelvir + ritonavir on CLL patient outcomes during the Omicron surge

Blood Podcast

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The NF1A ET02 Fusion Protein Interferes With Erythroid Differentiation

NF1A ET02 binds to mostly active chromatin and represses key regulators of terminal erythroid differentiation that contain nuclear factor I binding sites. TP53 R248Q by itself did not impact erythroids but provided self-renewal potential, primarily by down-regulating TP53 targets. Findings support a model in which NF1a ET02 enforces an immature and proliferative state in cells that are partially committed to the erythrogryd lineage.

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