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Episode 21 - The Coagulation Cascade Simplified

Trauma ICU Rounds

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The Dynamic Duo of Coagulation

This chapter explores the critical roles of protein C and protein S in the coagulation cascade, emphasizing their functions as vitamin K dependent proteins. Through a creative analogy likening protein C to Batman and protein S to Robin, the chapter highlights their interdependent roles in regulating blood clot formation. The discussion also addresses the implications of deficiencies in these proteins, particularly regarding the effects of anticoagulants like warfarin and conditions such as skin necrosis.

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