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CAR-T therapy in AML: challenges and future outlooks

VJHemOnc Podcast

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Factors Influencing CAR-T Therapy in AML and the Future of Off-the-Shelf T-cells

This chapter explores the factors that may contribute to the lack of efficacy in CAR-T therapy for AML, including the patient's T-cell disease or microenvironment. The potential of off-the-shelf donor T-cells is also discussed, along with the challenges of cytokine release syndrome and low response rates.

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