DMT may be possible that DMT activates the brain in a way that it is impossible to endogenously activate the brain. But generally speaking, I think that most things that drugs can do, we can get some kind of approximate experience ourselves. It's just about cultivating a particular kind of practice that like activates those receptors through that practice. A lot of the experiences people will describe with psychedelics are very similar to what I've experienced with meditation. The biggest difference is that in meditation, it's not as sexy for lack of a better term.