
Genetic shield against neurodegeneration
PNAS Science Sessions
Post-translational Modification of Tau Protein and Immune Response
This chapter explores the role of post-translational modifications, specifically acetylation of a tau protein segment called PHF6, in the aggregation and pathology of tau-related diseases. The researchers propose a potential protective mechanism of the immune system in clearing acetylated tau to prevent neurodegenerative diseases.
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