Amino Acids Supplements: Should You be Taking Them? | Dr. Robert Wolfe PhD
The Dr. Gabrielle Lyon Show
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The Randall Hypothesis and the Effect of Fatty Acids on Metabolism
The Randall hypothesis was put forth by Randall and Newsom back in 1963 based parenthetically purely on in vitro enzyme analysis. Their theory was that the availability of fatty acid dominated, but this had an inhibitory effect on the oxidation of glucose. And we did a series of two fairly straightforward experiments in human subjects testing the hypothesis,. In which case one, we had a high rate of carbohydrate oxidation dictated by glucose infusion so that 100% of the energy was coming from fatty, from glucose oxidation. We then had a 24th increase in fatty acid availability, and according to the theory, it should have inhibited glucose oxidation, but in fact had no impact at all. Then we did the reverse where we
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