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Audio long read: The ‘breakthrough’ obesity drugs that have stunned researchers
Nature Podcast
Type 2 Diabetes and Weight Loss
Before leptin's discovery, researchers have been looking for hormones that regulate blood glucose levels. GLP1 seemed to have the opposite effect of type 2 diabetes. In early 2021, scientists were wowed by a phase 3 clinical trial investigating a new drug called semagluetide. Tezepitide doesn't just target the GLP1 receptor, it also mimics another hormone involved in insulin secretion.
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