This chapter explores the intriguing relationship between psychedelic experiences and religious sentiments, suggesting historical roots for such encounters in the use of substances like dimethyltryptamine. It highlights the varying interpretations individuals have under the influence of psychedelics, addressing both the positive insights and potential negative repercussions. The conversation emphasizes the need for a balanced discourse about these experiences, acknowledging the stigma surrounding negative spiritual journeys alongside the healing potential of psychedelics.