#328 - Health & Longevity
Making Sense with Sam Harris - Subscriber Content
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The Causality of Smoking
Mendelian randomizations and RCT data make it abundantly clear that for every, you know, minimal reduction in LDL C, you have X reduction in the risk of AS CVD. The area under the curve of your exposure to LDL over a given period of time is proportional to your risk. So smoking is neither necessary nor sufficient to cause lung cancer, but it's causally related. But when it comes to APO-B, we have the same degree of causality. And therefore, if you really wanted to think of a thought experiment, if you took APo-B down to a physiologic level in a teenager, they couldn't get heart disease in their lifetime
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