Clinical trials in Alzheimer’s disease frequently include the measurement of risk genes (i.e., the APOE e4 allele), and advancements in direct-to-consumer genetic testing (e.g., 23andMe) have made these biological data widely available to the public. Is it helpful or harmful for clinicians to disclose information on genetic risk for Alzheimer’s disease to patients and research participants? How can we explain concepts such as risk and incomplete penetrance to our patients? We pose these questions, and others, to a neuropsychologist with research and clinical experience in this arena, as well as provide a primer on genetics.
Show notes are available at www.NavNeuro.com/13
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