Sepsis

The toxicity is more to do with the duration of therapy and lack of time free from dentomycin. So I don't think you can really cause harm generally speaking by a one-off dose of gents. Sometimes you would give it empirically before you even had the renal function. You want to get antibiotics in quickly. And then it comes back to the creatinum was actually 800 and they had a massive AKI. Whoops.