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Journal Club: Engineering Logic into CAR T Therapies with Robbie Majzner
Raising Health
The Role of Car T Signaling in the Killing of Target Cells
When a car interacts with its target antigen, this leads to turning on a cascade of intracellular messages. Our group wanted to find the minimal set of functionally necessary messages for this response. We rebuilt cars not to use CD3 Zeta, and just use these downstream messenger proteins.
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