Most people still think GLP-1s are "weight loss shots," but what we are really doing is changing biology at the level of appetite and inflammation, with ripple effects across future generations. In this conversation, I sit down with endocrinologist and obesity specialist Dr. Rocio Salas Whalen to unpack what these medications do inside the body and how to use them responsibly as part of a long-term health strategy.
We get into why "eat less, exercise more" failed so many patients, how family history, hormones, and aging drive obesity, and why GLP-1s must be paired with protein and strength training. We also explore GLP-1's impact on visceral fat, diabetes, brain health, what healthy weight loss looks like on a body composition scan, and how to avoid sarcopenia and the so-called "Ozempic face."
Dr. Rocio Salas-Whalen is a board-certified endocrinologist and obesity-medicine specialist, author of Weightless, and an early adopter of GLP-1 therapies. Her so-called "GPS framework", GLP-1, protein, and strength training, reflects her approach to evidence-based obesity care.
What's Discussed:
(00:00) GLP-1s and Weight Loss
(12:45) The Impact of GLP-1 Hormone
(25:29) Muscle Mass and GLP-1 Importance
(31:46) Optimizing Protein Intake on GLP-1
(43:24) GLP-1 Dosing and Gut Health
(48:20) Mental Health Implications of Weight Loss
(57:16) Weightless Book Pre-Order Announcement
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Learn more about Dr. Shah:
Website: https://www.drshah.com/
Clinic: https://www.next-health.com/
Instagram: https://www.instagram.com/darshanshahmd/
Learn more about Dr. Rocio Salas Whalen:
Website: https://www.nyendocrinology.com/dr-salas-whalen
IG: https://www.instagram.com/drsalaswhalen/
Threads: https://www.threads.com/@drsalaswhalen
Book: Pre-order Here!
