#470: Melatonin, Meal Timing & Glucose Tolerance
Sigma Nutrition Radio
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Is There a Circadian Rhythm in Glucose Tolerance?
There is still an underlying circadian rhythm in glucose tolerance. If we feed people the same meal, same calories, same macronutrients at 8am versus 8pm, we will typically get better glucose responses to the 8am meal than the 8pm meal. In otherwise healthy individuals, the magnitude of that difference might be relatively modest. But in people with metabolic disease or kind of on that beginning of that glucose intolerance spectrum, then the differences become increasingly larger and more relevant. It's something you've often identified as an area, not just clock time or even biological time, but front loading or back loading caloric intake.
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