Microbial Metabolites as Signals

In this episode, Dr. Jockers explores with Jason Prall how mitochondrial health and the gut microbiome are deeply connected, shaping energy, inflammation, and long-term resilience. You'll learn why mitochondria are far more than energy producers and how their communication drives whole-body health.

In this episode, you'll discover how the microbiome helps translate food into signals that influence mitochondrial function, metabolism, and cellular repair. Jason breaks down why diversity in the gut matters and how everyday choices quietly shape this internal dialogue.

In this episode, you'll hear practical insights on how sleep, light exposure, movement, fasting, and stress act as signals that either strengthen or weaken this mitochondrial–microbiome connection. The conversation leaves space to rethink how small lifestyle shifts can create powerful biological change.

In This Episode:

00:00 Introduction to Human and Mitochondrial DNA

04:06 Deep Dive into Mitochondria and Aging

14:01 Understanding the Gut Microbiome

25:38 Environmental Factors Affecting Health

29:19 Mindfulness and Detoxification

29:55 Impact of Thoughts on Health

31:06 Personalized Health Approaches

31:39 Universal Health Strategies

33:43 Importance of Sleep

37:19 Exercise and Movement

41:07 Fasting and Meal Timing

45:48 Stress and Recovery Balance

48:42 Final Thoughts and Resources

If you want practical, natural strategies to balance your hormones, heal your gut, boost your energy, and slow aging, don't miss The Dr. Josh Axe Show. Dr. Axe blends ancient wisdom with cutting-edge science and brings on world-class experts for unfiltered conversations you won't hear anywhere else. Transform your health from the inside out and subscribe to The Dr. Josh Axe Show, with new episodes every Monday and Thursday.

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"Every disease involves mitochondria—when mitochondrial function fails, the body breaks down."

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Resources:

• Paleovalley Bone Broth Protein: Save 15% on grass-fed bone broth protein at paleovalley.com/jockers.

Connect with Jason Prall:

• Book: https://amzn.to/3YC78Wt

• Website: humanlongevityfilm.com, beyondlongevitybook.com

Connect with Dr. Jockers:

• Instagram – https://www.instagram.com/drjockers/

• Facebook – https://www.facebook.com/DrDavidJockers

• YouTube – https://www.youtube.com/user/djockers

• Website – https://drjockers.com/

If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/