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Metformin and Aging
Metformin is the number one prescribed diabetic drug in the world for type 2 diabetes. It has been put forward as one of these potential drugs to slow aging. We did a 12 week exercise training study in older individuals, again, because I'm interested in the aging aspect of this. The people that came in with the highest mitochondrial function from respiratory were also the ones that came out of the study with the biggest detriments from metformin. And so then we hypothesize that if you're already unhealthy that metformin potentially has some benefit. But it actually might be worse than no benefit at all.