Why Promising Cardiovascular Drugs Failed

Howie and Harlan are joined by cardiologist Aakriti Gupta to discuss advances in minimally invasive heart valve treatment, her work to expand access to cardiovascular care through technology and AI, and a major clinical trial on aortic valve replacement. Howie examines claims that immigration is driving the surge in measles cases; Harlan discusses disappointing trial results for two drugs aimed at preventing cardiovascular disease.

Show notes:

September 11

9/11 Memorial & Museum: Marking the 25th Anniversary

Measles

CDC: Measles Cases and Outbreaks"

"No evidence linking illegal immigration to measles outbreak, despite Byron Donalds' comment".

"Kindergarten Routine Vaccination Rates Continue to Decline"

"'Real-life consequences': Pennsylvania Gov. Shapiro, RFK Jr. spar over measles-associated deaths"

"Two unvaccinated people die of measles in Pennsylvania"

Aakriti Gupta

Center for Outcomes Research & Evaluation (CORE)

Structural Heart Disease

Structural Heart Disease and Interventional Cardiology

Heart Valve Disease

Open-Heart Surgery

Transcatheter aortic valve replacement (TAVR)"

"Gender Bias in Choosing Cardiology, Training and Early Career Development"

Rajendra Makkar

Tia Health

Jeff Wessler

Heartbeat Health

Echocardiogram

iCardio.ai

AllHeart

BELIEVERS trial

Failed Drug Trials

"Novo Nordisk stops two cardiovascular studies aimed at lowering inflammation"

"Ionis partner Novartis announces Lp(a)HORIZON Phase 3 topline results for pelacarsen in patients with elevated Lp(a) and established cardiovascular disease"

Lipoprotein(a)

GLP-1 Agonists