In 1970, as a young assistant professor at Caltech, I started thinking about where I wanted my scientific career to go in the future. He developed six instruments that basically allowed one to read and write DNA - they served as the foundation of modern biology. And certainly they give us the ability to get big data from individual humans. In 2014 we created the first precision health medicine population with big data,. We generated from the blood, from the gut microbiome from digital health measurements, and the like. That would lead to two important results. One, an unequivocal proof of enormous increase in the quality of health care. Two, a demonstration that the science of wellness and the science of prevention would lead

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