Saturday Morning Coffee Talk | 1/3/26
The Hunter Williams Podcast
Orforglipron vs Peptide GLPs
Hunter compares small‑molecule Orforglipron to peptide GLPs on appetite suppression and metabolic effects.
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Timestamps:
00:14:36 – “What big trend in peptides do you see becoming popular?”
00:19:40 – “Using GLP-2 twice per week… how to switch to GLP-3 for maintenance?”
00:22:00 – “It’s hard to keep muscle mass on GLPs – what peptides help?”
00:23:36 – “Any peptides that stimulate hunger or appetite?” (Jay)
00:24:10 – “Did you experience anhedonia on RETA?”
00:31:00 – “IGF-1 LR3 stability – does it lose effectiveness after reconstitution?”
00:31:56 – “Does oral GLP (orforglipron) have benefits beyond appetite suppression?”
00:33:30 – “What is your New Year’s protocol / what are you experimenting with?”
00:36:59 – “Good starter protocol with SS-31, MOTS-C, BPC-157, Ipamorelin, CJC, RETA?”
00:39:46 – “Glutathione injections causing soreness – normal?”
00:40:00 – “How to reduce water retention on growth hormone peptides?”
00:41:30 – “Low iron in a 21-year-old, fatigue, and peptides for depression?”
00:43:24 – “Taste changes on RETA – is that common?”
00:44:16 – “Can GLPs cause hair thinning?”
00:44:34 – “Thoughts on Klotho?”
00:45:02 – “Why Ipamorelin over Tesamorelin for women?”
00:45:34 – “Peptide cheat sheet dosing – AM/PM split clarification?”
00:46:29 – “Will RETA ever be oral? (needle-averse)”
00:47:59 – “Best way to get Jardiance without Bitcoin?”
00:48:59 – “Any info on Stamakort-10?”
00:50:57 – “Can GLPs help reduce alcohol cravings?”
00:53:05 – “Can you talk more about MOTS-C?”
00:54:15 – “Does metformin deplete B-vitamins?”
00:55:14 – “Does topical GHK-Cu work for skin benefits vs injectable?”
00:57:39 – “Bioregulator capsules vs injectable effectiveness?”
01:03:26 – “Post-viral upper respiratory recovery – would VIP help?”
01:04:48 – “Best place to get testosterone for women?”
01:14:04 – “Insomnia on RETA – causes and fixes?”
01:21:25 – “Do you recommend topical estrogen?”
01:34:09 – “Growth hormone peptides after thyroid cancer – safe?”
01:37:14 – “Progesterone causes mood issues – alternatives?”
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