EP. 207: A new study on tirzepatide just dropped, and some obesity experts claim it confirms that the drug works only by reducing calories. After reading the full paper myself, I’ve got a different take. In this episode, I unpack what the study actually shows—like how tirzepatide increases fat oxidation without impacting metabolic adaptation—and why the “calories in, calories out” story doesn’t tell the whole truth. There’s more going on here, and you deserve the full picture.
Topics Covered:
- Does tirzepatide help with metabolic health beyond calorie restriction leading to weight loss?
- How does it affect metabolic adaptation in people with obesity?
- Can it boost fat oxidation?
- Is the “calories in, calories out” model outdated for GLP-1s?
- What does this mean for long-term metabolic health?
Sponsored By:
On This Episode We Cover:
- 00:00:00 – Introduction
- 00:02:44 – Obesity study on GLP1s and weight loss
- 00:04:21 – Calories in vs. calories out
- 00:05:44 – Resting metabolic rate
- 00:09:25 – Metabolic adaptation during dieting
- 00:12:11 – Tirzepatide dosing in clinical studies
- 00:15:49 – Maintaining weight loss
- 00:18:15 – GLP1s & increased fat oxidation
- 00:19:14 – GLP1 microdosing myths
- 00:26:06 – Metabolic rate drops vs. metabolic improvements
- 00:29:51 – Lessons from the Biggest Loser study
- 00:34:20 – Study Comparation
- 00:35:25 – Weight loss, inflammation, and aging
- 00:36:35 – Health autonomy
- 00:40:23 – Caloric restriction and the CALERIE study
Studies Mentioned:
Show Links
Further Listening:
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