The Biotin-Dependent Enzyme Pyruvate Carboxylase Promotes Clearance of Oxalates

It makes complete sense to me that reducing circulating oxalate beneath a certain threshold will stimulate the clearance of accumulated crystals. Formation of crystals would be a defense against biochemical toxicity, but at the expense of damaging connective tissues and mucous membranes. Reversing this process could temporarily increase biochemical toxicity. When crystals break up, they never fully solubilize automatically, so the breaking up of crystals could cause physical irritation of tissues.