The Interplay of Genetics and Appetite in Obesity Management

EP. 212: Today I’m joined by Dr. Spencer Nadolsky, obesity specialist, Lipidologist, and founder of Vineyard, a cutting-edge direct care platform. We’re diving deep into the conversation you’ve been asking for: the real story behind GLP-1s, obesity as a chronic disease, and why treating it goes far beyond weight loss.

We break down everything from proper dosing, common side effects, and the dangers of vanity prescribing to the systemic issues with telemedicine and PBMs. Dr. Nadolsky and I also discuss strength training, preserving muscle mass, and how GLP-1s may support metabolic and cardiovascular health beyond their FDA indications.

This episode cuts through the noise and misinformation. If you care about metabolic health, this one’s essential.

Topics Discussed: 

• What are the real benefits of GLP-1 medications beyond weight loss?

• Is obesity truly a chronic disease, and how should it be treated?

• What are the risks of GLP-1 vanity dosing and fast titration?

• How do GLP-1s impact muscle mass and metabolic health?

• Why are telemedicine and PBMs problematic for obesity treatment?

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On This Episode We Cover: 

• 00:00:00 – Introduction 

• 00:02:48 – GLP-1 Dosing 

• 00:06:35 – Side Effects of Vanity Dosing

• 00:08:51 – Reducing GLP-1 Dosing

• 00:12:27 – Med Spas & Telemedicine Risks

• 00:14:20 – Slow Titration for Better Tolerance

• 00:18:44 – Pharma Profits & Overdosing

• 00:20:49 – Obesity Treatment Pre & Post GLP-1s

• 00:27:58 – Obesity Is a Chronic Disease

• 00:32:45 – Defining obesity 

• 00:36:16 – The Role of Genetics in Obesity

• 00:38:59 – Lifestyle Factors Beyond Genetics

• 00:40:46 – Insurance Barriers & PBM Costs

• 00:44:37 – Anti-GLP-1 Bias in Healthcare

• 00:46:22 – Why Strength Training Matters

• 00:51:39 – New Doctors & Role of AI

• 00:53:38 – Protecting Muscle on GLP-1s

• 00:58:55 – No Shortcuts to Health

• 01:02:01 – The Vineyard

Show Links:

• Glp-1s Can Help Employers Lower Medical Costs In 2 Years, New Study Finds

Further Listening

• GLP1 Uncovered FREE 4 Part Video Series 

• Ozempic Done Right Playlist

• EP. 202 | The Fight for Affordable GLP1s & the Truth About Big Pharma | Dave Knap

Check Out Dr. Spencer

• Vineyard

• Instagram

• Website

• Podcast

Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.