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Why does B12 damaged by nitrous oxide require megadosed folic acid rather than normal levels of folate? | Masterjohn Q&A Files #265
Mastering Nutrition
The Biochemistry of Nitrous Oxide Toxicity Underlying Mechanisms
The B12 didn't work until it was paired with megadosed folic acid is what I mean by why it can be 12 only access megadose folic acid but on normal levels of folate. So if nitrous oxide depletes B12, you have a methyl trap because the five-methyl tetrahydra folate cannot give up its methyl group to B12. That makes sense because it's vulnerable to oxidation. If you don't have vitamin B12 available, then you will have a methyl... Yeah, I mean that makes sense.
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