EP31 – Propofol TCI Pharmacokinetics with Dr Anthony | CT10
Count to 10 - Anaesthetic Primary Podcast
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Understanding Propofol Pharmacokinetics
This chapter explores the Schneider model's application to target-controlled infusion of propofol, highlighting key pharmacokinetic concepts such as equilibration rate constants and time to peak effect. It examines the differences in dosing strategies for younger versus older patients, emphasizing patient variables that impact drug administration and the significance of effect site concentration. Mathematical calculations and comparisons between models enhance the understanding of how to achieve targeted plasma levels and manage anesthesia effectively.
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