The effective reps for muscle growth - straight sets vs intensifiers
The HyPaultrophy podcast
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The Secret of Stimulating Rep Theory
The primary source of fatigue is metabolite related. If you do a very light load strengthening set to failure, then it actually doesn't produce very much hypertrophy at all. When we add blood flow restriction in the form of coughs or bands, whatever we're doing, then those very light loads suddenly start producing the same amount of hypertrophy. That's just physiologically how they work.
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