Lecanemab, Clinical Trials, and the Importance of Clinical Meaningfulness
Dementia Matters
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The Challenges of Amyloid Tau Neurodegeneration in Clinical Research
The ATN approach formalizes this multi-dimensional approach to identifying and monitoring changes in Alzheimer's disease. The A is presence or absence of amyloid, as indicated by amyloid PET or cerebrospinal fluid or now blood tests. And the T plus or minus is an indication of whether there's significant accumulation of tangles of tau changes in brain,. again by tau PET or blood tests that indicate tau or cerebro Spinal fluid. N is extent of brain volume loss and loss of brain cells or neurodegeneration.
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