Mutations, Epimutations, and Aging Drivers

In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Albert-László Barabási, Professor at Northeastern University, to explore how networks shape health, aging, and nutrition. Barabási explains how biological and social networks influence resilience, robustness, and our ability to recover from stress or disease. He describes aging as a gradual loss of resilience, where the body becomes less able to bounce back from small disruptions.

The conversation moves into the world of nutrition, where Barabási introduces the concept of “nutritional dark matter.” He argues that food contains thousands of little-known molecules, many of which play key roles in health but remain largely unmapped and unstudied. Barabási breaks down how these compounds, especially those found in plants, support cellular function far beyond the traditional nutrients listed on food labels.

The episode closes with a look at ultra-processed foods and their link to disease risk. Barabási shares new research tools that can help people evaluate what they eat and make smarter choices. Throughout, he reminds listeners that strong connections, between cells, foods, and people, are at the heart of long, healthy lives.

Guest-at-a-Glance

💡 Name: Albert-László Barabási
💡 What he does: Professor of Network Science
💡 Company: Northeastern University
💡 Noteworthy: Known for pioneering network science, the Barabási–Albert model, and research linking complex networks to human health, aging, and nutrition.
💡 Where to find him: https://www.linkedin.com/in/albert-laszlo-barabasi-264060165
💡 Guest Lab Website: https://barabasi.com/

Episode highlights:

[00:00:00]: Introduction
[00:01:53]: Early Journey from Physics to Network Science
[00:02:57]: Statistical Physics and Complex Systems
[00:05:01]: Discovering Networks in Everyday Life
[00:07:19]: Network Medicine and Disease Spread
[00:08:28]: Robustness in Networks
[00:11:16]: Resilience in Networks and Real-World Systems
[00:14:31]: Biological and Ecological Examples of Resilience
[00:17:42]: Fixed Points, Tipping Points, and System Collapse
[00:18:45]: Applying Network Theory to Aging
[00:21:10]: Modeling Aging as Loss of Resilience
[00:23:02]: Explaining the Resilience Framework for Aging
[00:26:09]: Disease, Aging, and System Perturbations
[00:27:43]: Lifestyle Factors and Biological Age
[00:29:19]: Epigenetic Reprogramming and Longevity Potential
[00:33:41]: Nutrition, Food Networks, and Nutritional Dark Matter
[00:34:41]: Mapping Food Molecules and Network Medicine
[00:38:02]: Polyphenols and the Role of Plant Chemicals
[00:42:14]: Cataloging Food Chemistry and the Need for a Food Genome Project
[00:44:57]: Food Molecules as Drug Candidates
[00:48:38]: Ultra-Processed Foods and Health Risks
[00:53:54]: Measuring and Identifying Ultra-Processed Foods
[00:57:55]: Comparing Food Processing Methods
[01:02:26]: Rapid-Fire Questions: Network Concepts, Diet, and Longevity
[01:07:18]: Key Takeaway and Closing Remarks

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