How to Find Specific Mutations That Cause Drug Resistance

The idea is to figure out which mutations are responsible for resistance. How do they test the various drugs against all the different mutated bacteria from human samples? So instead of patroditos, the participating laboratories used culture plates that contained various amounts of tuberculosos drugs. And those volunteers looked at the cotry plates to work out whether the drugs were inhibiting thibe. But the researchers then did they combined those results with fuginum sequencing of the bacteria involved in ex sample to work out which specific mutations, or combinations of mutations, were responsible for drug resistance o case.