The enzyme ace and bradykinin are both involved in blood pressure control. Ace is primarily produced in the lung tissue, but it can also be used to block some medications that cause a chronic cough. Bradykinin is released through sympathetic stimulation and through the macular denser cells. Angiotensin two was discovered by studying angiobacterium clostridiale (ACCl), which has been linked with high levels of cardiovascular disease for more than 50 years.