The Role of Dose in Infectious Diseases

In terms of pure drug versus bad relationship, that I can't see any reason why you'd need to have more than that 40 to 70% time. But there is a fundamental effect of pathophysiology in some patient populations, which dictate a different plasma concentration being required for those patients. And so if it's a critically ill patient, well, we've got to be more aggressive in treatment. So let's not necessarily know where the one they think about one log versus two log, but subconsciously, I think you might want to be moreaggressive with my treatment on them.