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NITRIC Trial - Panel Discussion

Critical Care Reviews Podcast

CHAPTER

The Blinding of the Dream

I think you probably overpowered in this child, because you told me the minimal difference you were interested in was 40 hours and actually you got point estimates that are very tight and much smaller than that. We did not discuss at the outset essentially negative weight into mortality other than the adjudication of a value of zero. So that was not considered as an option. And then one last thing is it seems to be common practice now. Now it may well be related to when your statistical analysis plan was written actually to consider death as worse than zero ventilator free days and actually to consider it as minus one. I don't actually think it would have changed your results. All of those are nitp

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