Maximizing Muscle Growth: The Role of Myofibrillar Protein Synthesis

In this episode of Hypertrophy: Past and Present, Jake and Chris explore Sig Klein’s early A/B full body routine from the pre-steroid bodybuilding era before examining the claim that elevated myofibrillar protein synthesis blunts the effectiveness of subsequent workouts.

Key topics include:

• Sig Klein’s beginner routine
•  The difference between myofibrillar protein synthesis and hypertrophy stimulus
• What comparing one vs three set studies shows us about elevated synthesis timelines
• Why any overlap effect is small (and irrelevant for single-set workouts)
• Why the weekly net stimulus still favours three times per week over two times per week training