TWiV 847: On Dasher, on Dancer, on Corona and Lassa
This Week in Virology
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Vaccination of Guinea Pigs
Next they want to see what if we've immunize the guinea pigs now we have this virus that appears to be attenuated. So they immunize strain 13 guinea pigs hundred thousand p f u subcutaneously, or mock with p b s. And then they am wait 30 days a month, and then expose them to a hundred thousand pf, again subcutaneous, with lasa virus. The non codon optimized version is called i g g anti lassa i g g but not neutralizing - suggesting that neutralizing anna bodies did not play a role in the protection conferred by the vaccine. They didn't see any viremia. No lesions in the
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