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#133 – Manolis Kellis: Biology of Disease
Lex Fridman Podcast
How Do Pharmaceutical Therapeutics Work?
The first step is figure out the genetics. The second step is figuring out the nucleotide that is responsible or set of nucleotides. Number five and six is what are the targets? Now I know the regulator. I know the motif, I know the tissue and I know the variant. What does it actually do? So you have to now trace it to the biological process and the genes that mediate that biological process. Knowing all of this can now allow you to find the target genes. How? By basically doing perturbation experiments or by looking at the folding of the epigenome Or by looking at genetic impact of that genetic variant on the expression of genes.
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