4min chapter

The Peter Attia Drive cover image

#255 ‒ Latest therapeutics in CVD, APOE’s role in Alzheimer’s disease and CVD, familial hypercholesterolemia, and more | John Kastelein, M.D., Ph.D.

The Peter Attia Drive

CHAPTER

The Importance of Genetics in Premature ASCVD

About 5% of people with FH escape any disease symptoms at all. They seem completely immune to the elevated LDL cholesterol. In men, it is extremely rare to have that. And there are some explanations. Very frequently those women have very high HDL cholesterol. So they absolutely have something protective.

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