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Katalin Karikó — Forging the mRNA Revolution

The Joe Walker Podcast

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The Causal Hypothesis of Pseudoureidine

In 2002, 2003, we didn't know that pseudo ureidine and the ureidine is actually the same more weight. The base is both of them is uratseal. Only the link, how it's the base linked to the sugar is different. So very similar, and they couldn't identify because the bait was the same. We learned 10 years later, our messenger RNA also have pseudo Ureidine. We just didn't know at that time. And so you have to understand that we changed all of the nucleoside in those mRNA.

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