Sam Banister - The Art and Science of Designing Novel Psychoactive Therapeutics
Human 3 with Brom and Sam
00:00
Psychiatric Drugs
The five ah t two a receptor a has a number of different signalling pathways that can be activated when aligant and agonis ligon binds. It's not as simple as like an on off switch, you know? And so it makes it very difficult to disentangle what is causing what. A ligan bias is one of the terms, or a signalling bias. We know from a work out of brin rothslab and a number his collaborators that a bett arrestin i is very important. If these are activated excessively, that beate arrest and recruitment becomes sort of preferred and allows the a homeostasis for the cell to be maintained by pulling a those receptors
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