5min chapter

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#373 – Manolis Kellis: Evolution of Human Civilization and Superintelligent AI

Lex Fridman Podcast

CHAPTER

How to Transform the Human Condition

Deep learning can be used to learn cell specific networks across millions of cells. Large language models have also been extremely helpful for structure. In Alzheimer's just a few weeks ago we had a paper in nature looking at APOE4, the strongest genetic association with Alzheimer's. And we showed that it actually leads to a loss of being able to transport cholesterol in myelinating cells known as oligodendrocytes which basically protect the neurons. So all of these circuits are basically now giving us handles to truly transform the human condition. We're doing the same thing in cardiac disorders, in Alzheimer's, in neurodegenerative disorders, in psychiatric disorders.

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