Exploring the Role of Let7 miRNAs in Hemoglobin Switching

In this week's episode we’ll discuss the utility of MRD in identifying patients with NPM1 AML who benefit from allogeneic transplant in first remission, learn more about the contribution of circulating hematopoietic stem/progenitor cell subsets to human hematopoietic hemostasis, and discuss the role of Let-7 miRNAs in regulation of BCL11A transcription and hemoglobin switching. 

Featured Articles:

• Postinduction molecular MRD identifies patients with NPM1 AML who benefit from allogeneic transplant in first remission
• let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching 
• Circulating Hematopoietic Stem/Progenitor Cell subsets contribute to human hematopoietic homeostasis