3min chapter

LEVELS – A Whole New Level cover image

#214 - Is fructose a driver of Alzheimer’s disease? | Dr. Richard Johnson & Dr. Rob Lustig

LEVELS – A Whole New Level

CHAPTER

The Effects of Fructose on Insulin Levels

When we found that we could lower uric acid and prove this fructose, we realized that we were dealing with something that was working independently of calories. And so if we injected leptin in the rats, they kept eating. We also realized that obesity, most people with obesity have leptin resistance as well. So we went on and tried and showed that the fructose actually induced leptin resistance in the brain. The high fat diet alone did not, it was specific to fructose. It's involved in this side chain reaction of fructose metabolism.

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